| Date | Opponent | Location | Coverage | Time/Result |
| Sep. 3, 2010 | vs. West Virginia State | Indianapolis, Ind. | Stats | (25-12, 25-8, 25-17) 3-0 W |
| Sep. 3, 2010 | vs. Wayne State (Mich.) | Indianapolis, Ind. | Stats | (23-25, 25-27, 29-27, 13-25) 1-3 L |
| Sep. 4, 2010 | at #4 Indianapolis | Indianapolis, Ind. | Video Stats | (25-17, 23-25, 16-25, 13-25) 1-3 L |
| Sep. 4, 2010 | vs. Nova Southeastern | Indianapolis, Ind. | Stats | (25-21,22-25, 28-26, 25-22 ) 3-1 W |
| Sep. 7, 2010 | at Mars Hill* | Mars Hill, N.C. | Video Stats | (25-21, 25-23, 25-13) 3-0 W |
| Sep. 10, 2010 | at Brevard* | Brevard, N.C. | Stats | 7 p.m. |
| Sep. 11, 2010 | at Lenoir-Rhyne* | Hickory, N.C. | Stats | 2 p.m. |
| Sep. 14, 2010 | CARSON-NEWMAN* | Greeneville, Tenn. | Stats | 6:30 p.m. |
| Sep. 17, 2010 | CATAWBA* | Greeneville, Tenn. | Stats | 7 p.m. |
| Sep. 18, 2010 | WINGATE* | Greeneville, Tenn. | 2 p.m. | |
| Sep. 21, 2010 | at King (Tenn.) | Bristol, Tenn. | 7 p.m. | |
| Sep. 28, 2010 | LINCOLN MEMORIAL* | Greeneville, Tenn. | Stats | 6:30 p.m. |
| Oct. 1, 2010 | at Newberry* | Newberry, S.C. | 7 p.m. | |
| Oct. 2, 2010 | at Anderson (S.C.)* | Anderson, S.C. | 2 p.m. | |
| Oct. 5, 2010 | LIMESTONE | Greeneville, Tenn. | Stats | 6:30 p.m. |
| Oct. 8, 2010 | BREVARD* | Greeneville, Tenn. | Stats | 7 p.m. |
| Oct. 9, 2010 | LENOIR-RHYNE* | Greeneville, Tenn. | noon | |
| Oct. 12, 2010 | MARS HILL* | Greeneville, Tenn. | Stats | 7 p.m. |
| Oct. 15, 2010 | KING (Tenn.) | Greeneville, Tenn. | Stats | 7 p.m. |
| Oct. 16, 2010 | vs. Erskine | Banner Elk, N.C. | 1 p.m. | |
| Oct. 16, 2010 | at Lees-McRae | Banner Elk, N.C. | 3 p.m. | |
| Oct. 22, 2010 | at Catawba* | Salisbury, N.C. | 7 p.m. | |
| Oct. 23, 2010 | at Wingate* | Wingate, N.C. | 2 p.m. | |
| Oct. 26, 2010 | at Carson-Newman* | Jefferson City, Tenn. | 6:30 p.m. | |
| Oct. 29, 2010 | NEWBERRY* | Greeneville, Tenn. | Stats | 7 p.m. |
| Oct. 30, 2010 | ANDERSON (S.C.)* | Greeneville, Tenn. | noon | |
| Nov. 2, 2010 | at Lincoln Memorial* | Harrogate, Tenn. | 6:30 p.m. | |
| Nov. 6, 2010 | at Augusta State | Augusta, Ga. | 1 p.m. | |
| Nov. 12-14, 2010 | at SAC Tournament | Salisbury, N.C. | ||
| Nov. 18-21, 2010 | NCAA II Southeast Regional | Campus Site | ||
| Dec. 2-4, 2010 | at NCAA II National Championship Festival | Louisville, Ky. | ||
Record: 3-2 (1-0 conference) Home events are in bold. |